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1st-line ART optimization dossier.

What is the optimal first-line ART regimen?

The optimal first-line regimen in most resource-limited settings that we support is a 3-drug combination consisting of Tenofovir (TDF) + Lamivudine (3TC) + Efavirenz (EFV).  This dossier includes information on the following points:

  • How to phase in use of TDF
    • including renal function monitoring
  • Use of TDF in pregnant women
  • Safety of EFV in the first trimester of pregnancy
  • Which drugs to use in those co-infected with TB or active hepatitis B
  • The evolution in price of EFV

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